Endocrine Abstracts

Background: An increasing amount of biomedical data is becoming available, and methods are needed to tackle these “big data”.Methods: We performed a systematic evaluation of 138 environmental and behavioral factors in relation to bone mineral density (BMD) in the National Health and Nutrition Examination Survey (NHANES). Dual energy X-ray absorptiometry (DXA) scans were available for total body, head, pelvis and lumbar spine for 27,259 particip...

IntroductionIndividuals with type 2 diabetes mellitus (T2DM) are at an increased risk of developing fractures, despite higher mean BMI and BMD. Recently, clinically relevant sub-groups of T2DM have been characterised using biomarkers of glycemic metabolism.AimCharacterise T2DM sub-groups in a population-based setting and test for differences in fracture risk.Methods<p class="abstext...

Introduction: Osteoporosis is a prevalent skeletal disease associated with increased fracture risk, morbidity, and mortality. Several meta-analyses have investigated the association between non-genetic, non-pharmacologic factors and osteoporosis risk.Purpose: We aimed to perform an umbrella review of the literature to systematically evaluate the available evidence.Methods: Meta-analyses of observational studies evaluating the assoc...